Selected Perlmutter Lab imaging-related publications

Last (partial) update 9/98

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Peer-Reviewed Manuscripts:

  1. Perlmutter JS, Raichle ME: Pure hemidystonia with basal ganglion abnormalities on positron emission tomography. Ann Neurol 15:228-233, 1984.
  2. Fox PT, Perlmutter JS, Raichle ME: A stereotactic method of anatomical localization for positron emission tomography. J Comput Assist Tomogr 9:141-153, 1985.
  3. Perlmutter JS, Raichle ME: Regional blood flow in hemi-parkinsonism. Neurology 35:1127-1134, 1985.
  4. Perlmutter JS, Herscovitch P, Powers WJ, Fox PT, Raichle ME: Standardized mean regional method for calculating global positron emission tomographic measurements. J Cereb Blood Flow Metabol 5:476-480, 1985.
  5. Reiman E, Raichle ME, Butler FK, Herscovitch P, Robins E, Fox P, Perlmutter J: The application of positron emission tomography to the study of panic disorder. Am J Psychiatry 143:469-477, 1986.
  6. Perlmutter JS, Larson KB, Raichle ME, Markham J, Mintun MA, Kilbourn MR, Welch MJ: Strategies for the in vivo measurement of receptor binding using positron emission tomography. J Cereb Blood Flow Metabol 6:154-169, 1986.
  7. Perlmutter JS, Kilbourn MR, Raichle ME, Welch MJ: MPTP induced up-regulation of in vivo dopaminergic radioligand-receptor binding in man. Neurology 37:1575-1579, 1987.
  8. Videen TO, Perlmutter JS, Mintun MA, Raichle ME: Regional correction of positron emission tomography data for the effects of cerebral atrophy. J Cereb Blood Flow Metabol. 8:662-670, 1988
  9. Perlmutter JS, Kilbourn MR, Welch MJ, Raichle ME: Nonsteady-state measurement of in vivo receptor binding with positron emission tomography: "dose-response" analysis. J Neurosci. 9:2344-2352, 1989.
  10. Tempel LW, Perlmutter JS: Abnormal vibration-induced cerebral blood flow response in dystonia. Brain 113:691-707, 1990.
  11. Perlmutter JS, Lich LL, Margenau W, Buchholz S: PET measured evoked cerebral blood flow responses in an awake monkey. J Cereb Blood Flow Metab 11:229-235, 1991.
  12. Moerlein SM, Perlmutter JS: Evaluation of [F-18]fluoroethylketanserin for in vivo measurement of serotonergic S2 binding in brain with PET. Neurosci Ltr 123:23-26, 1991.
  13. Perlmutter JS, Moerlein SM, Huang D-R, Todd R: Non-steady-state measurement of in vivo radioligand binding with positron emission tomography: specificity analysis and comparison with in vitro binding. J Neurosci 11:1381-1389, 1991.
  14. Powers, WJ, Perlmutter JS, Videen TO, Herscovitch P, Griffeth LK, Royal HD, Siegel BA, Morris JC, Berg L: Blinded clinical evaluation of positron emission tomography for diagnosis of Alzheimer's disease. Neurology 42:765-770, 1992.
  15. Moerlein SM, Perlmutter JS: Binding of 5-(2'-[18F] fluoroethyl) flumazenil to central benzodiazepine receptors measured in living baboon with positron emission tomography. Eur J Pharmacol 218:109-115, 1992.
  16. Perman WH, Gado MH, Larson KB, Perlmutter JS: Simultaneous MR acquisition of arterial and brain signal-time curves. Magnetic Resonance in Medicine 28:74-83, 1992.
  17. Tempel LW, Perlmutter JS: Vibration-induced regional CBF responses in healthy aging. J Cereb Blood Flow Metabol 12:554-561, 1992.
  18. Moerlein SM, Perlmutter JS: Specific binding of 3N-(2'-[18F]fluoroethyl)benperidol to primate cerebral dopaminergic D2 receptors demonstrated in vivo by PET. Neurosci Lett 148: 97-100, 1992.
  19. Perman WH, El-Ghazzawy O, Gado MH, Larson KB, Perlmutter JS: A half-fourier gradient echo technique for dynamic MR imaging. Magnetic Resonance Imaging, 11: 357-366, 1993.
  20. Tempel LW, Perlmutter JS: Abnormal cortical responses to vibration in patients with writer's cramp. Neurology 43:2252-2257, 1993.
  21. Larson KB, Perman WH, Perlmutter JS, Gado MH: Tracer-kinetic analysis for measuring regional cerebral-blood flow by dynamic nuclear magnetic resonance imaging. J Theoretical Biology 170:1-14, 1994.
  22. Moerlein SM, Perlmutter JS, Welch MJ, Raichle ME: First-pass extraction fraction of iodine-123 labeled perfusion tracers in living primate brain. Nucl Med Biol 21:847-855, 1994.
  23. Moerlein SM, Perlmutter JS, Welch MJ: USP standards for raclopride C11 injection. Pharm Forum 21:172-176, 1995.
  24. Moerlein SM, Perlmutter JS, Welch MJ: Specific, reversible binding of [18F] benperidol to baboon D2 receptors: PET evaluation of an improved 18F-labeled ligand. Nucl Med Biol 22:809-815, 1995.
  25. Black KJ, Videen TO, Perlmutter JS: A metric for testing the accuracy of cross-modality image registration: validation and application. J Comput Assist Tomogr 1996; 20(5):855-861. [Medline]
  26. Sheline YI, Black KJ, Lin DY, Brunsden B, Gado M, Vannier M: Stereologic MRI volumetry of the frontal lobe using orthogonal views. Psychiatry Research--Neuroimaging 1996; 67(3):203-214. [Medline]
  27. Perlmutter JS, Stambuk MK, Markham J, Black KJ, McGee-Minnich L, Jankovic J, Moerlein SM: Decreased [18F]spiperone binding in putamen in idiopathic focal dystonia. J Neurosci 1997; 17(2):843-850. [Medline]
  28. Moerlein SM, Perlmutter JS, Welch MJ: In vivo kinetics of [18F](N-methyl)benperidol: a novel PET tracer for assessment of dopaminergic D2 receptor binding. (submitted)
  29. Moerlein SM, Perlmutter JS, Cutler PD, Welch MJ: Radiation dosimetry of [18F](n-methyl)benperidol as determined by whole-body pet imaging of primates. (submitted).
  30. Black KJ, Gado MH, Perlmutter JS: PET measurement of dopamine D2 receptor-mediated changes in striatopallidal function. J Neurosci 1997; 17(9):3168-3177. [Medline]
  31. Black KJ, Perlmutter JS: Septuagenarian Sydenham's with secondary hypomania. Neuropsychiatr Neuropsychol Behav Neurol 1997; 10(2):147-150.
  32. Perlmutter JS, Tempel LW, Black KJ, Parkinson D, Todd RD: MPTP induces dystonia and parkinsonism: clues to the pathophysiology of dystonia. Neurology 1997; 49(5):1432-1438.
  33. Black KJ, Gado MH, Videen TO, Perlmutter JS: Baboon basal ganglia stereotaxy using internal MRI landmarks: validation and application to PET imaging. J Comput Assist Tomogr 1997; 21(6):881-886. [Medline]
  34. Black KJ, Perlmutter JS: Can FDOPA PET help determine disease status in familial Parkinson's disease? Neurology Network Commentary 1997; 1(5):308-314.
  35. Black KJ, Öngür D, Perlmutter JS: Putamen volume in idiopathic focal dystonia. Neurology [in press]
  36. Hershey T, Black KJ, Stambuk MK, Carl JL, McGee-Minnich L, Perlmutter JS: Increased thalamic response in Parkinson's disease patients with dyskinesias. Proc Natl Acad Sci U S A [in press]
  37. Feiwell RJ, Black KJ, Snyder AZ, McGee-Minnich LA, MacLeod AK, Perlmutter JS: Diminished regional cerebral blood flow response to vibratory stimulation in patients with blepharospasm. Neurology [in press]
  38. Black KJ: On the efficiency of stereologic volumetry as commonly implemented for 3D digital images. [submitted]
  39. Hershey T, Black KJ, Stambuk MK, Carl JL, McGee-Minnich L, Perlmutter JS: Asymmetric levodopa-induced blood flow changes in putamen and amygdala in Parkinson's disease. [submitted]

    40. Black KJ, Hershey T, Gado MH, Perlmutter JS: Temporal lobe activation by a dopamine D1 agonist: a PET study in nonhuman primates using intersubject image averaging. [in preparation]

Invited Publications:

  1. Perlmutter JS, Raichle ME: In vitro or in vivo receptor binding: where does the truth lie? Ann Neurol 19:384-385, 1986.
  2. Perlmutter, JS: New insights into the pathophysiology of Parkinson's Disease: the challenge of positron emission tomography. Trends Neurosciences 11:203-208, 1988.
  3. Perlmutter JS: New techniques in neuroimaging: When are pretty pictures clinically useful? Current Opinion in Neurology & Neurosurgery. 6(6): 889-890, (Neuroimaging section editor-JS Perlmutter) 1993.
  4. Haller J, Botteron K, Brunsden B, Sheline Y, Walkup R, Black K, Gado M, Vannier M. Hippocampal MR volumetry. In Robb RA (ed.), Visualization in Biomedical Computing 1994, SPIE Proceedings 2359:660-671, 1994.
  5. Martin WRW, Perlmutter JS: Assessment of fetal transplantation in Parkinson's Disease: Does PET play a role? Neurology 44:1777-1780, 1994.
  6. Sheline YI, Black KJ, Lin DY, Pimmel J, Wang P, Haller J, Csernansky J, Gado M, Walkup R, Brunsden B, Vannier M. MRI volumetry of prefrontal cortex. In Loew MH (ed.), Image Processing, SPIE Proceedings 2434:766-770, 1995.
  7. Perlmutter JS: PET evaluation of dopaminergic pathways. Clin Neuropharmacol 18:S188-194, 1995.
  8. Perlmutter JS: MRI and PET investigations of Parkinson's disease. pp. 91-107, W.C. Koller, G Paulson (eds), Marcel Dekker New York 1995.
  9. Black KJ, Botteron KN: Neuroimaging in anorexia nervosa and bulimia nervosa. Pp. 267-295 in Krishnan KRR, Doraiswamy PM (eds.), Brain Imaging in Clinical Psychiatry. New York: Marcel Dekker, 1997.
  10. Perlmutter JS, Stambuk M, Markham J, Black KJ, McGee-Minnich L, Jankovic J, Moerlein SM: Decreased [18F]spiperone binding in putamen in dystonia. Pp. 161-168 in Dystonia 3 (Advances in Neurology vol. 78). Philadelphia: Lippincott-Raven, 1998.

Recent Abstracts:

  1. Moerlein SM, Perlmutter JS: Non-internalization of N-methyl-[F-18]benperidol: a PET radioligand that binds to dopaminergic D2 receptors with high specificity and reversibility. J Cereb Blood Flow Metabol 15:S644, 1995.
  2. Gado M, Black KJ, Perlmutter JS, Raichle ME. Effects of the selective dopamine D2 agonist U91356A on regional cerebral blood flow. Soc Neurosci Abstr 21(Part 2):856, 1995.
  3. Black KJ, Videen TO, Perlmutter JS. A metric for validating cross-modality image registration techniques. Soc Neurosci Abstr 21(Part 2):1208, 1995.
  4. Perlmutter JS, Giovanni J, Black KJ, McGee-Minnich L, Tempel LW, Moerlein SM. Abnormal [F18]spiperone binding in putamen in idiopathic dystonia. Soc Neurosci Abstr 21(Part 2):1429, 1995.
  5. van Meir H, Tempel LW, Perlmutter JS, Raichle ME, Petersen SE. Generalization of practice-related effects in motor learning using the dominant and non-dominant hand measured with PET. Soc Neurosci Abstr 21:1441, 1995.
  6. Moerlein SM, Perlmutter JS, Welch MJ. In vivo receptor binding by a unique PET D-2 radioligand: n-methyl-[F18]benperidol. Soc Neurosci Abstr 21:1621, 1995.
  7. Giovanni J, Perlmutter JS, Moerlein SM, Cutler PD, Anderson MM, Welch MJ. Whole-body biodistribution of the PET D2 radioligand N-methyl-[F18]benperidol in primates. Soc Neurosci Abstr 21:1621, 1995.
  8. Moerlein SM, Perlmutter JS, Welch MJ: D-2 binding by N-methyl-[F-18]benperidol is unaffected by endogenous dopamine. J Nucl Med 36:11P, 1995.
  9. Moerlein SM, Perlmutter JS, Anderson MM, Cristel ME, Stephenson M, Welch MJ: Metabolism in vitro of F-18 labeled benperidol derivatives by isolated rat hepatocytes. J Nucl Med 36:153P, 1995.
  10. Black KJ, Perlmutter JS: An in vivo test of striatopallidal sensitivity to a specific D2 agonist. Mov Disord 1996; 11(Suppl 1):108.
  11. Perlmutter JS, Black KJ, Stambuk M, McGee-Minnich L, Moerlein S: Location, location, location: putaminal [F18]spiperone binding in focal dystonia. Mov Disord 1996; 11(Suppl 1):218.
  12. Black KJ, Videen TO, Perlmutter JS: Regional effects of a D3-preferring agonist on cerebral blood flow. Soc Neurosci Abstr 1996; 22(Part 1):224.
  13. Stambuk M, Perlmutter JS, Black KJ, McGee-Minnich L: PET measurements of l-DOPA activation of human midbrain. Soc Neurosci Abstr 1996; 22(Part 1):229.
  14. Perlmutter JS, Stambuk M, Markham J, Black KJ, McGee-Minnich L, Moerlein SM: Decreased [18F]spiperone binding in putamen in idiopathic dystonia. Soc Neurosci Abstr 1996; 22(Part 1):498.
  15. Black KJ, Videen TO, Perlmutter JS: In vivo regional cerebral blood flow responses to a dopamine D1 agonist. J Neuropsychiatry Clin Neurosci 1997; 9(1):132.
  16. Black KJ, Öngür D, Gado MH, Perlmutter JS: Enlarged putamen in idiopathic focal dystonia. Soc Neurosci Abstr 1997; 23(Part 2):1909.
  17. Hershey T, Black KJ, Carl J, Perlmutter JS: Regional blood flow changes induced by l-DOPA methyl ester in normal monkeys. Soc Neurosci Abstr 1997; 23(Part 2):2038.
  18. Black KJ, Hershey T, Perlmutter J: Coupling of cerebral blood flow and metabolism in the presence of pramipexole. J Neuropsychiatry Clin Neurosci 1997; 9(4):700.
  19. Black KJ: On the efficiency of stereologic volumetry as commonly implemented for 3D digital images. Soc Neurosci Abstr 1998; 24(Part 1):1066.
  20. Hershey T, Black KJ, Stambuk MK, Carl J, McGee-Minnich LA, Perlmutter JS: Altered thalamic response to levodopa in Parkinson's patients with dopa-induced dyskinesias. Soc Neurosci Abstr 1998; 24(Part 1):1222.
  21. Perlmutter JS, Snyder AZ, Tolia VN, Revilla F, McGee-Minnich L, Moerlein SM, Black KJ: Does the spatial distribution of putaminal D2 receptors differ in patients with blepharospasm vs. hand cramp? Soc Neurosci Abstr 1998; 24(Part 2):1475
  22. Hershey T, Black KJ, Stambuk MK, Carl J, McGee-Minnich LA, Perlmutter JS: Mechanisms of dopa-induced dyskinesias in Parkinson's disease. Mov Disord 1998; [submitted]
WWW Publications:
  1. Black KJ, Videen TO, Perlmutter JS (1997): The "DH68" sterotactic atlas of baboon brain: definitions and reference data.
  2. Black KJ, Hershey T, Gado MH, Perlmutter JS (1997): D&H atlas volumes of interest for baboon PET studies.
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