Interventional neuroradiology,aneurysms,stroke,arteriovenous malformations,avm,angioplasty,gdc

Colin P. Derdeyn, M.D.
Professor of Radiology, Neurology and Neurological Surgery
Director, Center for Stroke and Cerebrovascular Disease

Program Director
Endovascular Surgical Neuroradiology (Interventional Neuroradiology Fellowship)

Cerebrovascular Group
NeuroImaging Laboratory

Interventional Neuroradiology Service
Neuroradiology Section
Mallinckrodt Institute of Radiology

NeuroVascular Program
Department of Neurological Surgery


Biographical Sketch

Dr. Derdeyn received both his BA (Echols Scholar Program, 1984) and MD (1988) from the University of Virginia. After a year as a intern in general surgery and a year as a resident in Neurological Surgery at the University of North Carolina, Chapel Hill, he became interested in the developing field of interventional neuroradiology. He completed a Radiology residency at the Mallinckrodt Institute of Radiology, Washington University School of Medicine, in 1994, where he served as Chief Resident his final year. This was followed by a year as a fellow in Diagnostic Neuroradiology at Mallinckrodt Insitute of Radiology. His final year of clinical training (1996) was spent gaining dedicated experience in neuro-endovascular techniques at the University of Wisconsin-Madison as a fellow in Interventional Neuroradiology. 

He is board certified in Radiology, with sub-specialty certification in Neuroradiology. He has been named to the Best Doctors list from 2005 to the present. He is an active member of several professional cerebrovascular and radiological societies. These include the Society of NeuroInterventional Surgery (SNIS, formerly the American Society of Interventional and Therapeutic Radiology), the American Society of Neuroradiology, the Stroke Council of the American Heart Association (Fellow), and the Joint Section on Cerebrovascular Surgery of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons.  He is a frequent ad hoc reviewer for several major journals and serves on the editorial board of Stroke and the American Journal of Neuroradiology.  He is a Past President of the Society of NeuroInterventional Surgery and currently serves on their Executive Committee. He chairs the Scientific Statement Oversight Committee for the Stroke Council of the Amercian Heart Association. He chairs two Data Safety Monitoring Boards for ongoing NIH-funded clinical trials: P50NS044378 "MR and Mechanical Revascularization of Stroke Clots using Embolectomy (MR-Rescue)" and P50NS044148 "The Intravascular Cooling in the Treatment of Stroke 2/3 Trial (ICTuS 2/3)"

Research Summary

The focus of my research is on stroke and cerebrovascular disease. I lead a large research team involved in translational research for better treatments of patients with acute stroke (P50 NS55977, Washington University SPOTRIAS (Specialized Programs of Translational Research in Acute Stroke) Center). I am also involved as an executive investigator in an NIH-funded multicenter randomized trial of angioplasty and stenting for symptomatic intracranial atherosclerotic disease (NS58728, Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) Trial).

One particular area of interest relates to cerebral hemodynamics. Severe hemodynamic impairment(reduced blood flow) may lead to stroke. This research primarily involves the use of a positron emission tomography (PET) scanner. PET uniquely allows the non-invasive measurement of cerebral blood flow and oxygen use (metabolism) in the brain. I am particularly interested in the responses of the brain blood vessels and the brain itself to reduced pressure in the arteries.  Current NIH-funded projects include a study of the role of cerebral hemodynamics on the risk of stroke in patients with Moyamoya disease, an unusual cause of arterial narrowing or blockage. 

In addition to the PET research, other areas of inquiry include the development of MR techniques to provide similar non invasive physiologic measurements as PET. This includes measurements of cerebral blood flow and blood volume, as well as a method to measure relative oxygen use in patients with cerebrovascular disease.

The ultimate aim of all these efforts is to develop better therapies to reduce the risk of stroke in patients with cerebrovascular disease.

Bibliography (pubmed search for all articles)

Colin P. Derdeyn, M.D. 
Program Director
Endovascular Surgical Neuroradiology 
Mallinckrodt Institute of Radiology 
Washington University School of Medicine 
510 South Kingshighway Blvd 
St. Louis, MO 63110-1093 

Bridget Filiput, R.N.
(314) 362-5580 
Fax (314) 362-4886 

Last updated 9/05/10.  Maintained with assistance from the Computer Support Group of the NeuroImaging Laboratory

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